Fig. 2

Identification of CSL and CSV interactions in cancer cells. A Bar charts show the numbers of CRs in different categories. B Specific roles of the CRs with two functions, including Dm & Hm (DNA methylation and histone modification), Dm & Cr (DNA methylation and chromatin remodeling), Hm & Cr (histone modification and chromatin remodeling). C Subgroups of the histone modifiers. D Subgroups of the DNA methylator. Dm, Hm and Cr depicts DNA methylator, histone modifier and chromatin remodeler. Two means two types, including W & R (Writer and Reader), W & E (Writer and Eraser) and R & E (Reader and Eraser). A denotes ambiguous. R, W and E represent reader, writer and eraser. E Overlapping of the candidate CSL interactions identified in functional screen datasets. F Overlapping of the candidate CSV interactions identified in functional screen datasets. G Statistics of CSL and CSV in different types of cancer cells