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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Omentin1 ameliorates myocardial ischemia-induced heart failure via SIRT3/FOXO3a-dependent mitochondrial dynamical homeostasis and mitophagy

Fig. 2

Fat-specific omentin1 overexpression up-regulated SIRT3-FOXO3a signaling and maintained mitochondrial dynamical homeostasis in HF mice. A Representative western blotting images of the expression of SIRT3 in myocardial mitochondria of mice with fat-specific omentin1 overexpression (n = 3). B Representative immunohistochemical images of the expression of SIRT3 in heart tissues of mice with fat-specific omentin1 overexpression, scale bar = 100 μm (n = 3). C Representative western blotting images of the expression of FOXO3a in heart tissues of mice with fat-specific omentin1 overexpression (n = 3). D Representative immunofluorescent images of the expression of FOXO3a in heart of mice with fat-specific omentin1 overexpression, scale bar = 20 μm (n = 3). Representative western blotting images of the expression of E Mfn2, F L-OPA1/S-OPA1 and G p-Drp1(Ser616)/Drp1 in myocardial mitochondria of mice with fat-specific omentin1 overexpression (n = 3). H Representative immunohistochemical images of the expression of Mfn2, OPA1 and p-Drp1(ser616) in heart tissues of mice with fat-specific omentin1 overexpression, scale bar = 100 μm (n = 3). Results were gained from three independent experiments and were expressed as mean ± SD. ##P < 0.01, ###P < 0.001, ####P < 0.0001 vs. the sham group; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. the model group. A–H one-way ANOVA

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