Fig. 1

Fat-specific omentin1 overexpression ameliorated cardiac function and myocardial injury in HF mice. A Serum omentin1 level of heart failure (HF) patients and healthy subjects. A total of 23 HF patients and 23 healthy subjects were enrolled. B The serum content of omentin1 in mice with fat-specific omentin1 overexpression by intravenous injection of AAV-omentin1 and negative control by intravenous injection of AAV-NC (n = 8). C The serum content of BNP in mice with fat-specific omentin1 overexpression (n = 6). D The serum CK activity in mice with fat-specific omentin1 overexpression (n = 6). E Representative echocardiographs of mice with fat-specific omentin1 overexpression and the statistical results of F left ventricular ejection fraction (LV EF), G fractional shortening (LV FS), H stroke volume (SV), I left ventricle posterior wall in diastole (LVPWd), (J) interventricular septum in diastole (IVSd), K relative wall thickness (RWT) and L left ventricular mass (LV Mass) were presented (n = 6). M Representative TTC staining images of heart tissues of mice with fat-specific omentin1 overexpression and the statistical results were presented (n = 3). N Representative images of H&E and Masson staining of heart tissues of mice with fat-specific omentin1 overexpression and the statistical results of O Masson staining and P H&E staining were presented (n = 3), scale bar = 250 μm. Results were expressed as mean ± SD. **P < 0.01 vs the healthy subjects group; ^####P < 0.0001 vs. the sham group; **P < 0.01, ***P < 0.001, ****P < 0.0001 vs the model group. A unpaired Student’s two-tailed t-test; B–P one-way ANOVA