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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: CDK1 serves as a therapeutic target of adrenocortical carcinoma via regulating epithelial–mesenchymal transition, G2/M phase transition, and PANoptosis

Fig. 6

CDK1 regulated the PANoptosis of ACC cells through binding to the PANoptosome in a ZBP1-dependent way. a Co-IP data showed that CDK1 could bind to the PANoptosome in SW-13 cells, and b in NCI-H295R cells. c Immunofluorescence showed that CDK1 co-localized with ZBP1 in SW-13 cells, and d in NCI-H295R cells. e Silencing ZBP1 could rescue cell death triggered by CurE in SW-13 and NCI-H295R cells. f Silencing ZBP1 inhibited the marker proteins of apoptosis, pyroptosis, and necroptosis. g Immunofluorescence showed that ZBP1 was upregulated by administration of CurE in vivo

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