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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: CDK1 serves as a therapeutic target of adrenocortical carcinoma via regulating epithelial–mesenchymal transition, G2/M phase transition, and PANoptosis

Fig. 2

CDK1 facilitated the epithelial-mesenchymal transition of ACC cells via Slug and Twist. a Overexpression of CDK1 elevated invasion and migration of SW-13 cells. b Knockdown of CDK1 expression reduced migration and invasion of NCI-H295R cells. c CDK1 regulated expression of metastasis-related proteins. d CDK1 interacted with Slug and Twist. e Knockdown of Slug reversed the pro-metastatic effect of CDK1. f Effect of Slug on CDK1-regulated pathways of metastasis. g Knockdown of Twist blocked CDK1’s pro-metastatic activity. h Effect of Twist on CDK1-regulated pathways of metastasis. i CDK1 influenced expression of Slug and Twist in vivo. Experiments were performed in triplicate, and data was presented as mean ± SD. ***P < 0.001 vs. control group

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Journal of Translational Medicine

ISSN: 1479-5876

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