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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: CDK1 serves as a therapeutic target of adrenocortical carcinoma via regulating epithelial–mesenchymal transition, G2/M phase transition, and PANoptosis

Fig. 1

CDK1 facilitated the proliferation of ACC cells both in vitro and in vivo. a Transfection efficiency of CDK1 overexpression in SW-13 cells. b Upregulation of CDK1 promoted growth of SW-13 cells. c Overexpression of CDK1 increased the colony formation of SW-13 cells in soft agar. d Upregulation of CDK1 facilitated the proliferation of SW-13 cells in 3D Matrigel. e Upregulation of CDK1 facilitated the proliferation of SW-13 cells in vivo. f Transfection efficiency of knockdown of CDK1 expression in NCI-H295R cells. g Downregulation of CDK1 suppressed growth of NCI-H295R cells. h Knockdown of CDK1 expression suppressed soft agar colony formation of NCI-H295R cells. i Downregulation of CDK1 suppressed growth of NCI-H295R cells in 3D Matrigel. j Downregulation of CDK1 suppressed growth of NCI-H295R cells in vivo. Experiments were performed in triplicate, and data was presented as mean ± SD. ***P < 0.001 vs. control group

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Journal of Translational Medicine

ISSN: 1479-5876

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