Detecting associated genes for complex traits shared across East Asian and European populations under the framework of composite null hypothesis testing

Table 1 Number of associated SNPs discovered by JST and CONTO for traits in the EAS and EUR populations

trait	JST (f₁₁)	CONTO			trait	JST (f₁₁)	CONTO
trait	JST (f₁₁)	f₁₀	f₀₁	f₁₁	trait	JST (f₁₁)	f₁₀	f₀₁	f₁₁
SCZ	21	0	186	57	eGFR	71	22	205	312
RA	27	5	48	87	ANM	28	7	100	127
T2D	293	115	310	824	PLT	261	29	429	625
COA	19	14	112	111	RBC	195	8	568	438
AOA	22	19	57	53	MCV	351	30	388	782
PCA	27	1	44	85	HCT	40	3	315	281
BMI	95	1	1027	291	MCH	251	20	316	726
Height	698	228	455	1544	MCHC	136	23	125	224
DBP	33	0	802	130	HGB	34	7	303	182
SBP	84	4	643	252	MONO	40	4	250	151
PP	57	2	315	122	NEUT	44	0	158	135
HDL	113	52	0	305	EO	40	2	259	173
LDL	74	22	18	166	BASO	32	5	29	101
TC	101	64	22	204	LYMPH	29	1	163	78
TG	42	41	14	109	WBC	69	12	149	259
HbA1c	56	47	34	96

f₁₀ and f₀₁ are the number of identified genes that were only associated with the trait in the EAS or EUR population, respectively, and f₁₁ is the number of shared associated genes in both populations
SCZ schizophrenia, RA rheumatoid arthritis, T2D type 2 diabetes, COA childhood-onset asthma, AOA adult-onset asthma, PCA prostate cancer, BMI body mass index, DBP diastolic blood pressure, SBP systolic blood pressure, PP pulse pressure, HDL high density lipoprotein cholesterol, LDL low density lipoprotein cholesterol, TC total cholesterol, TG triglyceride, HbA1c hemoglobin A1c, eGFR estimated glomerular filtration rate, ANM age at natural (non-surgical) menopause, PLT platelet count, RBC red blood cell count, MVC mean corpuscular volume, HCT hematocrit, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, BASO basophil count, LYMPH lymphocyte count, WBC white blood cell count

ISSN: 1479-5876