Fig. 7

XPO1 inhibitor KPT-330 inhibited growth of GBC in vivo with excellent drug safety. A Schematic diagram of GBC xenograft mouse model treated with KPT-330 in vivo. B Photograph of sacrificed nude mice in KPT-330 treatment group and vehicle treatment group. C Removed subcutaneous tumors from KPT-330 treatment group and vehicle treatment group. D Tumor volume in different weeks in KPT-330 treatment group and vehicle treatment group. E Removed subcutaneous tumors weight in vehicle or KPT-330 group. F Immunohistochemistry showed that XPO1, Ki67 and PCNA expression levels of xenograft tumor tissues were lower in KPT-330 treatment group. Scale bars represent 200 μm. G No obvious pathological changes in the lung, liver, kidney and heart were found after KPT-330 treatment. Scale bars represent 100 μm. Student's t test was applied to the statistical analysis in this figure