Table 2 General demographics and laboratory parameters of the original and revalidation cohort
From: Revalidating the prognostic COVID-19 severity assessment (COSA) score for variants of concern
Non-severe (N = 758) | Severe (N = 512) | |||||
|---|---|---|---|---|---|---|
Original (N = 457) | Revalidation (N = 301) | P value | Original (N = 171) | Revalidation (N = 208) | P value | |
Demographics | ||||||
Age (years) | ||||||
Median (IQR) | 64.00 (49.00, 76.00) | 72.00 (59.00, 82.00) | < 0.002 | 68.00 (57.00, 78.00) | 72.00 (59.75, 82.25) | 0.058 |
Sex | ||||||
Female, n (%) | 188 (41.05) | 125 (41.81) | 0.895 | 45 (26.32) | 63 (30.29) | 0.460 |
Hospitalization | ||||||
Inpatients, n (%) | 319 (69.58) | 299 (100.00) | < 0.002 | 163 (95.27) | 208 (100.00) | 0.005 |
Deaths | ||||||
Deceased, n (%) | 0 (0.00) | 0 (0.00) | – | 51 (29.82) | 120 (57.69) | < 0.002 |
Weight (kg) | ||||||
Median (IQR) | 77.90 (66.23, 88.00) | 76.30 (65.62, 88.00) | 0.526 | 81.00 (70.40, 93.70) | 75.20 (65.20, 90.00) | 0.026 |
Height (cm) | ||||||
Median (IQR) | 170.00 (165.00, 176.00) | 170.00 (163.00, 177.00) | 0.241 | 170.00 (165.00, 176.00) | 170.00 (165.00, 176.75) | 0.883 |
Body Mass Index (BMI, kg/m2) | ||||||
Median (IQR) | 25.98 (23.38, 29.74) | 26.20 (23.29, 30.32) | 0.489 | 28.07 (25.20, 31.20) | 26.87 (23.28, 29.81) | 0.018 |
Laboratory parameters | ||||||
Maximum C-reactive protein (CRP) levels | ||||||
Median (IQR) | 37.00 (10.00, 78.00) | 60.00 (21.00, 107.50) | < 0.002 | 106.00 (59.00, 175.00) | 125.50 (62.00, 202.50) | 0.300 |
Maximum sodium levels | ||||||
Median (IQR) | 139.00 (137.00, 141.00) | 139.00 (137.00, 142.00) | 0.262 | 142.00 (139.00, 145.00) | 142.00 (138.00, 146.00) | 0.901 |
Minimum hemoglobin levels | ||||||
Median (IQR) | 132.00 (118.00, 144.00) | 126.00 (111.00, 142.00) | 0.004 | 113.00 (89.50, 125.00) | 107.50 (84.75, 124.25) | 0.372 |
Minimum glomerular filtration rate (GFR) values | ||||||
Median (IQR) | 82.00 (61.00, 97.00) | 75.00 (52.00, 93.00) | 0.007 | 64.00 (39.50, 87.00) | 56.00 (31.75, 84.25) | 0.158 |
Minimum glucose values | ||||||
Median (IQR) | 6.40 (5.67, 7.90) | 6.90 (6.00, 8.46) | 0.002 | 9.50 (7.46, 12.55) | 9.45 (7.18, 11.80) | 0.393 |
Minimum leukocytes values | ||||||
Median (IQR) | 6.32 (4.70, 8.61) | 6.41 (4.91, 9.09) | 0.235 | 8.92 (6.65, 13.70) | 10.90 (7.03, 15.12) | 0.072 |