The potential impact of a probiotic: Akkermansia muciniphila in the regulation of blood pressure—the current facts and evidence

Table 1 Current literature review about the role of A. muciniphila on small rodent HTN model

Study title	Animal	Comparison	Akkermansia muciniphila abundance	References
High-salt (HS) diet-induced hypertension model	Sprague–Dawley rat	Control vs HS groups	No change	Ding et al. [170]
Acute Intra-abdominal (aIAH) HTN model	Sprague–Dawley rat	Control vs IAH groups	No change	Leng et al. [171, 172]
Spontaneous-hypertensive rat (SHR) models	SHR rat	SHR vs WKY2 groups	Decreased [173] and increased (not statistically significant), no change	Abboud et al. [173], Singh et al. [174], Li et al. [170], Wu et al. [175, 176]
High carbohydrate and fat diet-induced hypertension	Wistar rats	diet-induced HTN vs control groups	Increased (not statistically significant)	Thomaz et al. [177]
High fat diet-induced cardiometabolic disorders	Wistar rats	HFD diet vs control groups	No change	de Araujo Henriques Ferreira et al. [178]
High fat-diet underwent vertical sleeve gastrectomy (VSG) surgery	C57BL/6 J	Sham vs VSG groups	No change	McGavigan et al. [179]
Altitude variation model	Mus musculus domesticus	Comparison at different altitude	Decreased in higher altitude	Suzuki et al. [122]

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