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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: SGLT2 inhibitors improve kidney function and morphology by regulating renal metabolic reprogramming in mice with diabetic kidney disease

Fig. 1

Effect of empagliflozin on the biochemical assay and renal pathology of db/db mice. A The workflow of the animal experiment. B Bodyweight changes of mice during the intervention. C Fasting-blood glucose levels of mice during the intervention. D–G The level of serum cystatin C (D), blood urea nitrogen (E), urine creatinine (F), urine microalbumin (G) in different groups. H Representative renal tissue pathology (× 200) of mice in each group (H&E staining, PAS staining, and Masson staining). I, J The average glomerular perimeters (I) and glomerular area (J) based on 10 randomly consecutive fields in each section from H&E staining. K, L The percentages of glomerular (K) and interstitial (L) fibrosis based on 10 randomly consecutive fields in each section from Masson staining. “*”, “#”, and “&” mean p < 0.05 when db/m vs. db/db, Empa vs. db/m, and Empa vs. db/db, respectively. “ns”, not significant

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