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Table 4 The 8 target proteins related biological functions or etiology in multiple tumors according to previous literature's reported (partial)

From: From Bowen disease to cutaneous squamous cell carcinoma: eight markers were verified from transcriptomic and proteomic analyses

Protein

Tumor

Regulated

Biological functions or etiology

COL1A1

Lung cancer [12]

Up

COL1A1 was correlated with immune infiltrating levels, including CD4+ T cells, macrophage, neutrophil, and dendritic cell in lung cancer

Mesothelioma [13]

Up

COL1A1 expression was significantly correlated to the infiltration levels of CD4+ T cells, macrophages, and neutrophils in Mesothelioma

COL3A1

Ovarian carcinomas [14]

Up

COL3A1 higher expression was associated with shorter overall survival

CD36

Ovarian cancer [15]

Up

The omental adipocytes could reprogram tumour metabolism through the upregulation of CD36 in Ovarian cancer cells

TNC

Colorectal cancer [16]

Up

Higher expression of TNC was correlated with a poorer prognosis in stages II and III of CRC.

Glioblastoma [17]

Up

Decreased TNC in the tumor microenvironment modulated behaviors of stromal cells, resulting in enlarged tumor blood vessels and activated microglia in tumors. Tenascin-C knockdown cells were sensitive to Temozolomide therapy

FSCN1

Renal cell carcinoma [18]

Up

Higher expression of FSCN1 led to an up-regulation of MMP9 and N-Cadherin in Renal cell carcinoma. Inhibition of PI3K/AKT or knockdown GSK-3βcould decreased the expression of FSCN1, and then attenuated Renal cell carcinoma invasion

 

Adrenocortical carcinoma [19]

Up

FSCN1 higher expression was associated with worse prognoses; Higher expression of FSCN1 was associated with the tumour microenvironment and immune signatures in Adrenocortical carcinoma

ACTN1

Oral SCC [20]

Up

Inhibition of ACTN1 could induce cell cycle arrest, promote apoptosis, and inhibit EMT and cell proliferation, migration, and invasion in the OSCC cell lines

Hepatocellular carcinoma [21]

Up

ACTN1 associated with Hippo signaling pathway activity and decreased Rho GTPases activities

RAB31

Pancreatic cancer [22]

Up

RAB31 higher expression was associated with shorter overall survival

Cervical cancer [23]

Up

RAB31 knockdown inhibited the epithelial-mesenchymal transition and cytoskeletal rearrangement in cervical cancer cells. Overexpression of RAB31 inhibited MAPK6 degradation

SERPINB1

Glioma [24]

Down

SERPINB1 inhibited glioma migration and invasion probably by dampening the expression of matrix metalloproteinase-2