Fig. 5

The immunosuppressive phenotype of solid LUAD-derived DCs. A UMAP plot colored by DC subtypes. B Heatmap of normalized expression of DC marker genes among subtypes. C. Boxplot showing cellular fractions of each DC subtype in normal (n = 5), acinar (n = 4) and solid (n = 4) samples. Box centerlines, median; box limits, the 25th and 75th percentiles; box whiskers, 1.5 × the interquartile range. Line segments of different lengths indicate which two groups were compared. Two-sided Wilcoxon rank-sum test. D. Violin plots of immunosuppressive molecules expression in mregDC from solid and acinar samples. E. Violin and box plots of antigen presentation (left) and immunosuppressive (right) signature scores for DCs in the three subgroups. Comparisons were performed by two-sided Wilcoxon rank-sum test