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Table 2 SPR binding affinities (Kd, n = 3) of HuB6 to human FcγRs

From: A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity

FcγR type

Kon (1/Ms)

Koff (1/s)

Kd (nM)

IA

531,000

0.0045

8.86 ± 2.20

IIA

NB

NB

NB

IIB

NB

NB

NB

IIIA (F176)

NB

NB

NB

IIIA (V176)

NB

NB

NB

  1. NB, no measurable binding within the tested concentrations
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Journal of Translational Medicine

ISSN: 1479-5876

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