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Table 1 Comparison of the binding affinities (Kd, n = 3) of mAbs to human 4-1BB

From: A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity

Antibody

Kon (1/Ms)

Koff (1/s)

Kd (nM, SPR)

Kd (nM, BLI)

4-1BBL competition

Urelumab

209,700

0.0011

5.34 ± 0.49

5.76 ± 0.85

No

Utomilumab

504,900

0.0089

17.69 ± 1.92

22.12 ± 3.75

Yes

HuB6

94,260

0.0018

18.56 ± 2.49

13.98 ± 2.60

Yes

  1. Yes/No indicates whether 4-1BBL can compete for binding to 4-1BB
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Journal of Translational Medicine

ISSN: 1479-5876

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