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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity

Fig. 7

HuB6 has a good safety profile. a Humanized 4-1BB model mice were intraperitoneally injected with HuB6, utomilumab, urelumab or an isotype control once every 3 days (6 times total). The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the low-dose (3 mg/kg) group and high-dose (30 mg/kg) group were measured on the 16th day. *p < 0.001. b, c Eight male and 8 female cynomolgus monkeys were randomly divided into the low-dose (3 mg/kg), middle-dose (10 mg/kg) and high-dose (30 mg/kg) HuB6 groups and an isotype group, and the antibodies were administered via repeated intravenous infusions (once a week for 5 weeks). The evaluated serum biochemical markers included ALT, AST, creatinine (CREA) and UREA (b), and the hematological indexes included red blood cells (RBCs), white blood cells (WBCs), platelets (PLTs) and lymphocytes (LYMPHs) (c). d, e Six male and 6 female cynomolgus monkeys were randomly divided into the low-dose (60 mg/kg) and high-dose (180 mg/kg) HuB6 groups and an isotype control group, and the antibodies were administered only once via intravenous infusion. The evaluated serum biochemical markers included ALT, AST, CREA and UREA (d), and the hematological indexes included RBCs, WBCs, PLTs and LYMPHs (e)

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