Fig. 6
HuB6 does not induce the production of proinflammatory cytokines. The levels of the cytokines IFN-γ, TNF-α, IL-10, IL-2, IL-6, IL-4, and IL-17A in the culture medium with PBMCs (2 × 105 cells/well) from 5 healthy donors treated with 10 µg/mL of the tested antibodies for 48 h were measured by cytometric bead array assay. HuB6 was compared with the isotype control human IgG4 and the positive control antibody OKT3