Fig. 4

11β-HSD1 knockdown alleviated spatial learning and memory deficits in PTZ-induced epilepsy mice. A, B 11β-HSD1 knockdown significantly decreased seizure score and prolonged the number of days (latent period) required to reach complete kindling (n = 8 for the epilepsy and the Con-shRNA groups; n = 9 for the Con-shRNA and the 11β-HSD1-shRNA groups). C–F 11β-HSD1 knockdown significantly decreased escape latency, number of crossing of the target quadrant, swimming length and swimming velocity. (*P < 0.05, epilepsy group vs control group, Con-shRNA group vs 11β-HSD1-shRNA group). The bars indicated the mean ± SD