Fig. 3

11β-HSD1 knockdown exerted anticonvulsant profile in PTZ-induced epilepsy mice. A Images showing GFP expression in the hippocampus four weeks after injection of recombinant AAV (cell nuclei were counterstained with DAPI). The scale bar = 200 μm. B, C Western blot images showing 11β-HSD1 expression in PTZ kindling mice intra-hippocampal injected with recombinant AAV containing 11β-HSD1 shRNA or control shRNA. D, E Western blot images showing 11β-HSD1 expression in the hippocampus of the control group, the epilepsy group, the Con-shRNA group and the 11β-HSD1-shRNA group (*P < 0.01, epilepsy group vs control group, Con-shRNA group vs 11β-HSD1-shRNA group). The bars indicated the mean ± SD