Skip to main content
Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Atrial myocyte-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation

Fig. 7

The miR-210-3p-mediated GPD1L/PI3K/AKT signaling pathway contributes to fibrosis and the changes are reversed by LY294002. A KEGG pathway analysis of signaling molecules downstream of GPD1L. B, C Western blot analysis of the levels of the PI3K, P-AKT and AKT proteins in atrial fibroblasts (*P < 0.05, **P < 0.01, and ***P < 0.001). D, E Western blot analysis of the levels of the TGFβ1, Collagen I and Collagen III proteins in atrial fibroblasts (*P < 0.05). F CCK-8 assay of atrial fibroblast proliferation (##P < 0.01 compared with NC and **P < 0.01 compared with si-GPD1L + LY294002). G Immunofluorescence staining showed the relative expression levels of α-SMA (green) and DAPI (blue) in atrial fibroblasts. Scale bar: 50 μm

Back to article page