Fig. 4

Effect of miR-210-3p KO on cardiac features and function in Ang II-infused rats. A Representative echocardiographic images captured 4 weeks after the Ang II infusion in rats that received KO-miR-210-3p treatment. B The LAD was calculated at 4 weeks in rats (n = 7; *P < 0.05 for the comparison of the WT + Ang II and KO + Ang II groups). The EF%, FS% and RAD calculated at 4 weeks in rats (n = 7; ns for the comparison between the WT + Ang II and KO + Ang II groups). C Representative ECG traces after atrial burst pacing (left) at 3000 beats/min. D Probability of AF induction by atrial burst pacing of the induced AF episodes (n = 7; *P < 0.05 for the comparison of the WT + Ang II and KO + Ang II groups). E AERP measurement in rats (n = 7; ns for the comparison of the WT + Ang II and KO + Ang II groups). F The atrial myocyte cross-sectional area was calculated with Image J software. Scale bar: 50 μm (n = 7; **P < 0.01). G Atrial fibrosis (the ratio of the fibrotic area to total atrium area) was measured using Image J software. Scale bar: 50 μm (n = 7; ***P < 0.001). H Representative images of HE staining of atrial samples; the results are graphed for representative bright field images. I Representative images of Masson’s trichrome staining of atrial samples