Table 3 Testing for an interaction between the polygenic susceptibility to melanoma and survival prognostic factors in the MIA Cohort
Model | N | Events | HR | 95% CI | P-value |
|---|---|---|---|---|---|
PRS + Age + Sex + Breslow + Stage + 10PCs + Batch | 5282 | 669 | 0.84 | 0.78–0.91 | 1.9 × 10–5 |
PRS*Stage + Age + Sex + Breslow + 10PCs + Batch | 5282 | 669 | 0.82 | 0.75–0.91 | 1.6 × 10–4 |
PRS*Breslow + Stage + Age + Sex + 10PCs + Batch | 5282 | 669 | 0.84 | 0.70–1.01 | 0.060 |
PRS*Breslow*Stage + Age + Sex + 10PCs + Batch | 5282 | 669 | 0.85 | 0.70–1.03 | 0.095 |