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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting

Fig. 3

Stratified analysis of the PRS and MSS association by the AAJC Stage and primary tumour thickness in the MIA Cohort. The y-axis represents the hazard ratio for MSS per standard deviation (SD) increase in the PRS. Error bars show the 95% confidence interval of the HR. The x-axis shows the strata for tumour stage and thickness at diagnosis of melanoma. The dashed grey line represents a null effect at a hazard ratio of 1. Panel 3a shows the association between the CM PRS and MSS stratified by the AJCC 2010 tumour stage, after controlling for age at diagnosis, sex, the first 10 ancestral components and genotype batch effects. Stage I/II included 4493 participants and 427 melanoma deaths, while stage III/IV included 789 participants and 242 melanoma deaths. Panel 3b reports the association of the CM PRS and MSS stratified by the primary tumour thickness, after controlling for age at diagnosis, sex, the first 10 ancestral components and genotype batch effects. The thin (< = 1 mm) stratum included 1,898 participants and 122 melanoma deaths, while the thick (> 1 mm) stratum included 3,384 participants and 547 melanoma deaths

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