Fig. 4

Heat maps of read counts of small RNAs. The figure shows the heat maps comparing the read counts of small RNAs derived from serum EV and whole serum (figure A and B) and small RNA derived from CSF EV and whole CSF (figure C and D). The 50 most down-regulated small RNAs (figure A and C), and the 50 most upregulated (figure B and D) small RNAs in whole serum and whole CSF are displayed. Dendrograms to the right of the heatmaps cluster the RNA species, dendrograms on top of the heat maps display the clustering of the samples; underneath the heat maps the sample code is depicted. More heat maps comparing further pairs of comparisons are shown in Additional file 1: Fig. S8.