Fig. 1

Read counts, RNA content, percentage of small RNAs mapping to the human genome, and percentage of small RNA species detected. Figure A depicts the read counts and mean ± S.D. of samples derived from CSF (black full circles, left y-axis) and CSF-derived EV (black empty circles, left y-axis), as well as the RNA content and mean ± S.D. of the same samples (black full triangles represent whole CSF and black empty triangles represent CSF-EV, both right y-axis). Figure B shows the read counts with mean ± S.D. of samples derived from RNA of whole serum (black full squares, left y-axis) and serum-derived EV (black empty squares, left y-axis), as well as the RNA content with mean ± S.D. of the same samples (whole serum samples are shown as full black circles and serum EV samples are shown as black empty circles, both right y-axis). Figure C displays the percentage of small RNAs mapping to the human genome. Samples from whole CSF (full black circles), from CSF-derived EV (black empty circles), from whole serum (full black squares) and from serum-derived EV (black empty squares) ± their S.D. are shown. The levels of significance are given (****p < 0,0001, ***p < 0,0005, **p < 0,005, two-tailed Mann Whitney test). Figure D displays the percentage of small RNA species detected out of all known small RNA genes of the human genome