Fig. 5

Efficacy of anti-TSLP antibody in Lat mice. A Lat mice was administered 50 µg anti-TSLP antibody (n = 5) in 0.2 mL of PBS or PBS (n = 5) intraperitoneally once a week starting from 4 weeks of age until 7 weeks, and were sacrificed at 8 weeks of age. Weight changes from 4 to 8 weeks (B), plasma TSLP levels at 8 weeks (C), morphology (D) and weight of submandibular glands (SMGs), lung, liver, kidneys, and spleen in Lat mice with PBS (left) and Lat mice with anti-TSLP therapy (right). Representative H&E-stained sections (×100) (F), comparison of inflammatory area (G), representative Masson’s trichrome stained sections (×100) (H), and comparison of fibrosis area (I) of SMGs, pancreas, lung from WT mice, Lat mice with PBS and anti-TSLP therapy