| Years | NO | VEGF/VEGF-R | GDM/ Eclampsia/PE | Supplement | Cite |
---|---|---|---|---|---|---|
1 | 2016 | ↑ (Availability of NO decreased) | VEGF | GDM | The change of NO may be related to oxidative stress mechanism. May be related to post-transcriptional and translational NO synthase (NOS) regulation, including phosphorylation/dephosphorylation cycles | [60] |
 |  | ↓ | VEGF | PE | Same as above |  |
2 | 2012 | ↑ | VEGF | GDM | Altered endothelial L-arginine/NO signaling pathway | [61] |
 |  | ↓ |  | PE | Arginine deficiency recorded in the pre-placenta leads to a decrease in NO and an increase in superoxide formation |  |
3 | 2011 | unclear | VEGF | GDM | NO regulates the vascularization of pregnancy complications such as GDM and PE | [71] |
 |  |  | VEGF-R | PE | Same as above |  |
4 | 2017 | ↑ | VEGF | GDM | L-arginine/NO signaling pathway | [72] |
5 | 2019 | ↓ | VEGF-R(sFlt-1) | PE | There was a certain correlation between NO,sFlt-1 and BNP | [58] |
6 | 2015 | ↓ (severe) ↓↓ (mild) | PLGF | PE | The changes of PLGF and NO levels in groups may be closely related to the pathogenesis and development of early-onset PE | [59] |
7 | 2009 | ↓ | VEGF | PE | The expression of nitric oxide in patients with eclampsia was higher than that in patients with preeclampsia | [73] |
 |  | ↓↓ | VEGF | Eclampsia | Same as above |  |