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Table 2 NO impacted in GDM,PE/ Eclampsia and its association in this regard with VEGF

From: Vascular endothelial growth factor and its receptors regulation in gestational diabetes mellitus and eclampsia

 

Years

NO

VEGF/VEGF-R

GDM/ Eclampsia/PE

Supplement

Cite

1

2016

↑

(Availability of NO decreased)

VEGF

GDM

The change of NO may be related to oxidative stress mechanism. May be related to post-transcriptional and translational NO synthase (NOS) regulation, including phosphorylation/dephosphorylation cycles

[60]

  

↓

VEGF

PE

Same as above

 

2

2012

↑

VEGF

GDM

Altered endothelial L-arginine/NO signaling pathway

[61]

  

↓

 

PE

Arginine deficiency recorded in the pre-placenta leads to a decrease in NO and an increase in superoxide formation

 

3

2011

unclear

VEGF

GDM

NO regulates the vascularization of pregnancy complications such as GDM and PE

[71]

   

VEGF-R

PE

Same as above

 

4

2017

↑

VEGF

GDM

L-arginine/NO signaling pathway

[72]

5

2019

↓

VEGF-R(sFlt-1)

PE

There was a certain correlation between NO,sFlt-1 and BNP

[58]

6

2015

↓ (severe)

↓↓ (mild)

PLGF

PE

The changes of PLGF and NO levels in groups may be closely related to the pathogenesis and development of early-onset PE

[59]

7

2009

↓

VEGF

PE

The expression of nitric oxide in patients with eclampsia was higher than that in patients with preeclampsia

[73]

  

↓↓

VEGF

Eclampsia

Same as above

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