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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Association of peripheral basophils with tumor M2 macrophage infiltration and outcomes of the anti-PD-1 inhibitor plus chemotherapy combination in advanced gastric cancer

Fig. 4

Correlation of tumor infiltration with basophils and M2 macrophages. a Representative immunohistochemical images of basophils stained with an anti-ProMBP1 antibody and of M2 macrophages stained with an anti-CD163 antibody on paraffin sections of primary tumors. Scale bar, 50 μm. b The peripheral basophil counts were plotted against basophil numbers in primary tumors of corresponding patients. c Representative immunofluorescence images of basophils (green) and M2 macrophages (red) in gastric cancer tissues showing their spatial proximity. Scale bar, 20 μm. d The peripheral basophil counts were plotted against M2 macrophage counts in primary tumors of corresponding patients. e, f The tissue basophil counts were plotted against tissue M2 macrophage counts and PD-L1 expression in primary tumors of corresponding patients. Arrows show the spatial proximity between basophils and M2 macrophages. ProMBP1 (pro-major basic protein 1), PD-L1, programmed death ligand-1

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