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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: The potential of mecciRNA in hepatic stellate cell to regulate progression of nonalcoholic hepatitis

Fig. 5

A Novel Immunotyping of NASH Based on mecciRNA-related Network. A The heatmap shows the expression profiles of 21 specific targets from 16 steatotic liver tissues. B NASH patients clustering heatmap, consensus matrix k = 2. C PCA diagram shows the significant differences between 2 clusters of NASH patients (Cluster 1 labeled with blue, Cluster 2 labeled with red). D The volcano plot shows the upregulated (red) and downregulated (blue) genes in Cluster 1 vs. Cluster 2. P-value < 0.05 and |Log2FC|≥ 1.0. E The results of GO enrichment analysis for differentially expressed genes between Cluster 1 and Cluster 2. The names of GO terms are shown in Table.1. F, G The results of KEGG enrichment analysis for differentially expressed genes between Cluster 1 and Cluster 2. The names of KEGG terms are shown in Table.2. H, I Differential enrichment scores of 23 immune cell signatures in Cluster 1 and Cluster 2. *P < 0.05, **P < 0.01, n.s. means none was statistically significant

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