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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Low mitochondrial DNA copy number induces chemotherapy resistance via epithelial-mesenchymal transition by DNA methylation in esophageal squamous cancer cells

Fig. 5

Relationship between mtDNA, mitochondrial membrane potential and DNA methylation. A mtDNA-depleted TE11 cells had approximately twofold higher mRNA expression levels of DNMT1, DNMT3A and DNMT3B than control cell lines. B mtDNA-depleted TE11 cells had higher protein expression levels of DNMT1, DNMT3A and DNMT3B than control cells. Control-sh cells had higher protein expression of TFAM that tfam-sh cells. *The densitometry of relative protein expression. C mtDNA-depleted TE11 cells had approximately 10% more overall DNA methylation than control cell lines. D The mRNA expression levels of DNMT1, DNMT3A and DNMT3B were approximately 100–200% higher in CCCP-exposed cell lines than in control cell lines. E There were higher protein expression levels of DNMT1, DNMT3A and DNMT3B in TE11 cells exposed to 40 µM CCCP than in control cells. *The densitometry of relative protein expression

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