Fig. 6

AML PDX mice overexpressing HO1 were resistant to the killing effect of NK cells. A Schematic of PDX mouse experiment. B Flow cytometry profiles showing human AML blast (CD45+) in PB, BM, spleen, and liver from mice in each group. C Wright’s staining analysis under a 100× oil immersion objective for peripheral blood from mice in each group showed AML development (Scale bars = 10 μm). D One mouse from every group was sacrificed to obtain images and weights of spleens. E Representative HE-stained sections of spleens from all groups. Scale bars: 20 μm. F Representative Ki67 stained sections of spleens from all groups. The Ki67 immunohistochemistry scores were shown in histogram. Scale bars: 100 and 50 μm from up to down. *p < 0.05, ***p < 0.001, ^##p < 0.01 and ^###p < 0.001 were calculated using the Student’s t-test