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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Lkb1 aggravates diffuse large B-cell lymphoma by promoting the function of Treg cells and immune escape

Fig. 5

Lkb1 is upregulated in Tregs from DLBCL patients. A The results of qPCR were presented as mean values of relative Lkb1 mRNA expression levels to the housekeeping genes GAPDH, in healthy donors (n = 7), DLBCL patients (n = 6) and the patients after treatment (n = 9) respectively. B Automatic Simple Western system analysis. The ratio of the peak area of Lkb1 normalized to GAPDH from the same sample was presented, demonstrating that DLBCL patients (n = 3) had higher Lkb1 level than healthy donors (n = 3). C mRNA expression of mevalonate pathway genes of Tregs from DLBCL patients (n = 5) compared with that from control group (n = 7). D Relative Lkb1 mRNA expression levels to the housekeeping genes GAPDH, in B lymphoma and control group, respectively. n = 5. *P < 0.05; **P < 0.01, ***P < 0.001. In A, p values were determined by one-way ANOVA; In B–D, p values were determined by two-sided unpaired t-test; data are presented as mean values ± SEM

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