Fig. 4

Transcriptional profiling of Tregs among patients with DLBCL. A DEGs in DLBCL patients compared with the healthy donors in volcano plot. B Tregs function-related genes differentially expressed between Tregs from DLBCL patients and healthy donors determined by transcriptional profiling. Fold difference means fold change of gene expression levels in Tregs from DLBCL patients compared with that from control group. C, D Gene pathways that were differentially expressed in Tregs from DLBCL patients versus healthy donors by Gene Set Enrichment analysis and KEGG enrichment analysis. Gene sets were considered statistically significant at an FDR P-value < 0.05. E GO enrichment analysis of the results using the GO database. Genes were enriched in different categories in the GO terms analysis. F Expression profile of Lkb1 in Tregs from RNA- sequencing and expression of lipid metabolic pathway genes of Tregs from DLBCL patients compared with that from control group from RNA- sequencing