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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: circCRKL, a circRNA derived from CRKL, regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation

Fig. 6

circCRKL absorbs miR-877-5p to augment BCR-ABL and to accelerate CML cells proliferation. A, B CCK-8 assay was conducted to measure the cell growth co-transfected with circCRKL knockdown lentivirus and miR-877-5p inhibitor. C, D Colony formation assay was performed to determine the proliferation in CML cells co-transfected circCRKL knockdown lentivirus and miR-877-5p inhibitor. E The BCR-ABL protein levels were detected by western blot assays with co-transfecting circCRKL knockdown lentivirus and miR-877-5p inhibitor. F The BCR-ABL protein levels were determined using western blot assays with co-transfecting circCRKL knockdown lentivirus and miR-877-5p mimic. G Schematic diagram illustrates that circCRKL promotes CML cells proliferation via miR-877-5p/BCR-ABL axis. *p < 0.05, **p < 0.01 and *** < 0.001

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