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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Probiotics ameliorate IgA nephropathy by improving gut dysbiosis and blunting NLRP3 signaling

Fig. 5

SCFAs provided significant renal protection and distinctly reduced urine protein levels, alleviated inflammation, inhibited excessive mesangial proliferation, and improved the degree of renal fibrosis in IgAN. a Glomerular IgA immunofluorescence in mouse kidney. b PAS staining of wild-type normal controls (WC group), wild-type mice with IgAN (W-IgAN group), W-IgAN treated with probiotics (W-IgAN + B group), W-IgAN treated with sodium acetate (W-IgAN + SA group) and W-IgAN treated with sodium propionate (W-IgAN + SP group). c Collagen 1 immunofluorescence in the mouse glomerulus. d The average fluorescence intensity of IgA in mouse kidney. ef The urinary protein/creatinine ratio and serum creatinine levels of the mice in different groups. gi The serum inflammatory indicators of each group were measured by enzyme-linked immunosorbent assay. j The average fluorescence intensity of collagen 1 in mouse kidney. k The relative gene expression of collagen 1 in mouse kidney tissue. * 0.01 < P ≤ 0.05. ** 0.001 < P ≤ 0.01. *** P ≤ 0.001

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