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Fig. 8 | Journal of Translational Medicine

Fig. 8

From: SPOP promotes cervical cancer progression by inducing the movement of PD-1 away from PD-L1 in spatial localization

Fig. 8

SPOP can promote the immune tolerance of PD-1 via CXCL16. A CXCL16 transient siRNA-knockdown in HeLa cells with SPOP knockdown did not increase SPOP expression, but only reduced the increased-CXCL16 expression. B–D The results of CCK-8, colony formation and invasion assays showed that CXCL16 knockdown could reverse these phenotypes. E, F The IC50 results showed that CXCL16 knockdown could functionally reverse immune tolerance

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Journal of Translational Medicine

ISSN: 1479-5876

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