Fig. 5

SPOP promotes CC proliferation and metastasis in vivo. A Xenografts were established in BALB/c nude mice by subcutaneously injecting SPOP-knockdown HeLa cells (shRNA1) or vector-expressing cells (NC). B Xenograft tumour growth curves of the shRNA1 and NC groups. Final tumour weights of xenograft tumours at sacrifice. C Micro-PET-CT imaging (the red circle indicates metastasis of CC). D SPOP knockdown markedly reduced F18-FDG uptake into the tumours in vivo