lncRNA-AC079061.1/VIPR1 axis may suppress the development of hepatocellular carcinoma: a bioinformatics analysis and experimental validation

Table 3 The univariate and multivariate analysis of hsa-miR-765 and clinicopathological features of HCC patients

Characteristics	Total(N)	Univariate analysis		Multivariate analysis
Characteristics	Total(N)	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
T stage	371
T1 & T2	279	Reference
T3 & T4	93	2.617 (1.834–3.736)	< 0.001	1.844 (0.250–13.590)	0.548
N stage	260
N0	256	Reference
N1	4	2.051 (0.503–8.372)	0.317
M stage	275
M0	271	Reference
M1	4	4.083 (1.284–12.990)	0.017	2.005 (0.614–6.544)	0.249
Pathologic stage	350
Stage I & Stage II	261	Reference
Stage III & Stage IV	90	2.519 (1.731–3.665)	< 0.001	1.452 (0.198–10.648)	0.713
Histologic grade	370
G1&G2	232	Reference
G3&G4	139	1.068 (0.744–1.533)	0.721
Gender	374
Female	119	Reference
Male	256	0.799 (0.558–1.143)	0.219
Age	374
≤ 60	178	Reference
> 60	196	1.222 (0.860–1.738)	0.263
Vascular invasion	319
No	208	Reference
Yes	112	1.337 (0.882–2.028)	0.172
hsa-miR-765	374
Low	188	Reference
High	187	1.437 (1.012–2.043)	0.043	1.579 (1.011–2.466)	0.044

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