Table 1 The top 5 KEGG and GO analysis results of VIPR1-related genes

BP

GO:0,019,933

cAMP-mediated signaling

7/11

187/18670

2.88e−12

1.77e−09

1.01e−09

BP

GO:0,019,935

cyclic-nucleotide-mediated signaling

7/11

215/18670

7.73e−12

2.38e−09

1.35e−09

BP

GO:0,007,187

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

7/11

256/18670

2.64e−11

5.42e−09

3.09e−09

BP

GO: 0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

6/11

139/18670

6.85e−11

1.05e−08

6.00e−09

BP

GO: 0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

6/11

221/18670

1.13e−09

1.18e−07

6.74e−08

CC

GO: 0043204

perikaryon

2/11

134/19717

0.002

0.068

0.044

CC

GO: 0030666

endocytic vesicle membrane

2/11

167/19717

0.004

0.068

0.044

CC

GO: 0044233

Mitochondria-associated ER Membrane

1/11

13/19717

0.007

0.068

0.044

CC

GO: 0030479

actin cortical patch

1/11

16/19717

0.009

0.068

0.044

CC

GO: 0034045

phagophore assembly site membrane

1/11

16/19717

0.009

0.068

0.044

MF

GO: 0017046

peptide hormone binding

4/11

49/17697

1.69e−08

4.89e−07

2.13e−07

MF

GO: 0042562

hormone binding

4/11

102/17697

3.33e−07

4.82e−06

2.10e−06

MF

GO: 0005179

hormone activity

4/11

122/17697

6.83e−07

6.61e−06

2.88e−06

MF

GO: 0008528

G protein-coupled peptide receptor activity

4/11

146/17697

1.40e−06

9.55e−06

4.16e−06

MF

GO: 0001653

peptide receptor activity

4/11

152/17697

1.65e−06

9.55e−06

4.16e−06

KEGG

hsa04080

Neuroactive ligand-receptor interaction

6/11

341/8076

2.09e−06

1.38e−04

1.19e−04

KEGG

hsa04024

cAMP signaling pathway

4/11

216/8076

1.42e−04

0.004

0.003

KEGG

hsa04911

Insulin secretion

3/11

86/8076

1.81e−04

0.004

0.003

KEGG

hsa04270

Vascular smooth muscle contraction

3/11

135/8076

6.83e−04

0.011

0.010

KEGG

hsa04924

Renin secretion

2/11

69/8076

0.004

0.050

0.043