Fig.2

Dynamic change of genomic features in ctDNA correlated with clinical efficacy during chemotherapy. A: values of CCF, TMB, CNI and CNV burden at baseline (BL), progressive disease (PD) and during treatment (PR, SD). B: correlation between ΔTMB of ctDNA and patients’ outcomes of first-line therapy. C: dynamic changes of genomic features in ctDNA and tumor volumes in three typical cases