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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level

Fig. 6

Aberrant ferroptosis and pyroptosis involved in the pathological process of CD. (A) Dot plot showing the expression levels of pro-ferroptosis genes within fibroblasts of CD samples and control samples. (B) Selected representative genes are shown in monocle2 produced pseudotime trajectory plots of fibroblasts under different conditions. Violin plots showing the expression levels of ferroptosis suppressor genes (C), ferroptosis driver genes (D), and pyroptosis-related genes (E) within epithelial cells of CD samples and control samples. (F) The expression levels of NCOA4, GPX4, NFE2L2, FTH1, FTL, P4HB, PRDX1, and SLC40A1 within myeloid cells of CD samples and control samples. (G, H) Selected important genes were shown in monocle2 produced pseudotime trajectory plot under different conditions. (I) i. The schematic of bulk RNA-seq of THP-1-derived cells. ii. Heatmap depicted gene expression levels of macrophage-related genes (M1: IL18, IL1B, and TNF; M2: IL10 and TGFB1). iii. Heatmap of expression levels of pyroptosis-related genes. iv. Heatmap shows expression levels of ferroptosis-related genes

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Journal of Translational Medicine

ISSN: 1479-5876

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