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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level

Fig. 4

Ferroptosis-sensitivity was increased with decreasing expression of ferroptosis-resistant genes in brain cells of patients with MS. (A) Violin plot showing the ferroptosis suppressor geneset score in the different brain-derived cell subsets. (B) Dot plot showing the expression levels of GPX4, FTH1, MT1G, CISD, ISCU, PARK7, TF, and MTF1 within neurons of MS groups and control groups. Dot plot showing the expression levels of ferroptosis-resistant genes within oligodendrocytes (C), astrocytes (D), OPCs (E), and EC/VSM (F) derived from MS groups and control groups. (G) Schematic depiction of ferroptosis-sensitive state under MS pathological condition

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