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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level

Fig. 1

The expression patterns of ferroptosis and pyroptosis-related genes in different keratinocyte subtypes. (A) Dot plot shows the expression levels of pro-ferroptosis and ferroptosis-resistant genes in total keratinocytes derived from psoriasis skin and healthy skin. (B) Dot plot shows the expression levels of feature genes in different keratinocyte subsets. (C) The expression levels of GPX4, FTL, FTH1, NR4A1, NFE2L2, and MT1G in different subsets. (D) Quantification of pyroptosis geneset score of keratinocytes in psoriasis skin and healthy skin. (E) Dot plot shows the expression levels of CASP1, CASP4, CASP6, CASP8, CASP3, GSDMA, GSDMB, GSDMC, GSDMD, and GSDME in different keratinocyte subsets derived from psoriasis skin and healthy skin. (F) Schematic depiction of the relationship of psoriasis pathological process with ferroptosis/apoptosis/pyroptosis

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Journal of Translational Medicine

ISSN: 1479-5876

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