Fig. 2

Process of Clustering TCGA Bladder Cancer Data by TIME Phenotype A Unclustered TCGA bladder cancer RNA-Seq data set of the previously identified 939 TIME genes; B Patients are put into three groups on both the x- and y-axes via k-means clustering; C Hierarchical clustering is performed within each of the three groups on the x- and y-axes, respectively; D Each patient’s IO Score is overlaid above the heatmap, both as a continuous variable (top bar) and as a binary score with a threshold of 0.09