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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Translation of the 27-gene immuno-oncology test (IO score) to predict outcomes in immune checkpoint inhibitor treated metastatic urothelial cancer patients

Fig. 1

Isolating a Tumor Immune Microenvironment (TIME) Gene Set A Downloaded the full dataset of gene expression data in Breast Cancer from the TCGA Database; B Compared against an established 101-gene molecular classifier for TNBC [18] to correspond with three known signatures: IM, M, and MSL, and selected the top 1,000 genes correlated with each of the IM, M, and MSL signatures; C Repeated with TCGA gene expression data sets from Lung Adenocarcinoma and Lung Squamous Cell Carcinoma; D Identified top 1,000 genes for each signature in each additional cancer dataset; E Intersection of top 1,000 genes in each subtype between three cancers yielded a total of 939 genes

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Journal of Translational Medicine

ISSN: 1479-5876

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