A fetal fraction enrichment method reduces false negatives and increases test success rate of fetal chromosome aneuploidy detection in early pregnancy loss

Table 3 Regression analysis of factors for predicting fold-change of fetal fraction in 102 pregnancies with male fetuses

Independent variable	Univariate analysis		Multivariate analysis
Independent variable	Regression coefficient (95%CI)	P	Regression coefficient (95%CI)	P
Gestational age (week)	0.151 (0.070–0.232)	< 0.001	0.167 (0.094–0.241)	< 0.001
BMI (kg/m²)	0.120 (0.071–0.170)	< 0.001	0.075 (0.031–0.119)	< 0.001
Fetal fraction without enrichment (%)	− 0.040 (− 0.079 to − 0.002)	0.040	− 0.070 (− 0.103 to − 0.037)	< 0.001
Average size of cfDNA (bp)	− 0.043 (− 0.063 to − 0.023)	< 0.001	− 0.035 (− 0.051 to − 0.018)	< 0.001

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