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Table 3 Regression analysis of factors for predicting fold-change of fetal fraction in 102 pregnancies with male fetuses

From: A fetal fraction enrichment method reduces false negatives and increases test success rate of fetal chromosome aneuploidy detection in early pregnancy loss

Independent variable Univariate analysis Multivariate analysis
Regression coefficient (95%CI) P Regression coefficient (95%CI) P
Gestational age (week) 0.151 (0.070–0.232)  < 0.001 0.167 (0.094–0.241)  < 0.001
BMI (kg/m2) 0.120 (0.071–0.170)  < 0.001 0.075 (0.031–0.119)  < 0.001
Fetal fraction without enrichment (%) − 0.040 (− 0.079 to − 0.002) 0.040 − 0.070 (− 0.103 to − 0.037)  < 0.001
Average size of cfDNA (bp) − 0.043 (− 0.063 to − 0.023)  < 0.001 − 0.035 (− 0.051 to − 0.018)  < 0.001