Table 2 Drugs that stimulate IDO/Kyn pathway
From: IDO/kynurenine pathway in cancer: possible therapeutic approaches
| Â | Drug | Main target | Species | Model or cells | References |
|---|---|---|---|---|---|
1 | Statin | IDO1 (Gene expression) | Human | Asthma | [98] |
2 | Nandrolone decanoate | IDO1 (IDO activity) | Murine | Depression | [99] |
3 | Escitalopram | Kyn (enzyme–substrate binding) | Human | Neurotoxicity | [100] |
4 | Dexamethasone | IDO1 (IDO activity) | Human | Peripheral blood monocytes | [101] |
5 | Valproate | Kyn (enzyme–substrate binding) | Murine | Brain | [102] |
6 | Interferon | IDO1 (IDO activity) | Human | Peripheral blood monocytes | [101] |
7 | Tocilizumab | IDO1 (IDO activity) | Human | Diabetes | [103] |