Fig. 7

High levels of PCBP1 and DKK1 expression in LUAD predict good clinical outcome. A Representative images of DKK1 IHC staining; scale bars, 100 μm. The expression of DKK1 in peritumor and tumour tissues evaluated by immunohistochemistry. B Representative images of β-catenin IHC staining; scale bars, 100 μm. The expression of β-catenin in peritumor and tumour tissues evaluated by immunohistochemistry. C Kaplan–Meier analysis of overall survival was stratified by the protein expression levels of DKK1 and β-catenin. D Comparison of DKK1 and β-catenin protein expression detected by IHC between patients with different tumour sizes, N stages and tumour stages. E Representative images of PCBP1, DKK1 and β-catenin IHC staining; scale bars, 100 μm. F The correlation between PCBP1, DKK1and β-catenin at the protein level. G Correlation analysis of PCBP1 and DKK1 in TCGA and GSE19188. H Graphical summary of the PCBP1-DKK1- β-catenin axis regulating the proliferation and migration of lung cancer cells. *p < 0.05; **p < 0.01; ns, not significant