Fig. 6

PCBP1 inhibits tumour growth and metastasis in LUAD in vivo. A Body weight of the mouse A549 cell lung metastasis model. B Representative macroscopic lung images upon necropsy of mice with postimplant shPCBP1 and control A549 cells and HE images. C Quantification of lung metastases in mice bearing either shPCBP1 or control tumours. D Body weight of the mouse H358 cell lung metastasis model. E Representative macroscopic lung images upon necropsy of mice with postimplant shPCBP1 and control H358 cells and HE images. F The number of nodules per lung was quantified by HE staining. G, H A549 and H358 cells stably transfected with control and shPCBP1 were injected subcutaneously into nude mice. Tumour growth curves were plotted. I A549 cells stably transfected with control and PCBP1 were injected subcutaneously into nude mice. Tumour growth curves were plotted. (J) The weights of the excised tumours were measured. *p < 0.05; **p < 0.01; ns, not significant