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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: The RNA-binding protein PCBP1 represses lung adenocarcinoma progression by stabilizing DKK1 mRNA and subsequently downregulating β-catenin

Fig. 5

PCBP1/DKK1/β-catenin regulates migration and EMT in LUAD cells. A Western blotting analysis of the expression of β-catenin, phosphor-β-catenin, Vimentin, Claudin-1, PCBP1 and Tubulin. B shPCBP1 A549 cell migration was estimated by Transwell assays. C The knockdown efficiency of DKK1 in A549 cells was determined by RT–qPCR analyses. D Western blot assays were used to examine the expression levels of DKK1, β-catenin, phospho-β-catenin, Vimentin, Claudin-1, PCBP1 and Tubulin in A549 control, A549 PCBP1-OE, A549 PCBP1-OE + siDKK1#1, and A549 PCBP1-OE + siDKK1#2 cells. (E) Cell migration was determined by Transwell assay in each group. *p < 0.05; **p < 0.01; ns, not significant

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Journal of Translational Medicine

ISSN: 1479-5876

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